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Polyvalent Equine Purified Concentrated Liquid of Anti Gas Gangrene Sera
2 to 8 deg C
Mixed Gas Gangrene Antitoxin B.P.
For prophylaxis (Sepsis, Oedema, Necrosis caused due to Clostridium perfringens, Cl.novyi (oedematiens), Cl.septicum)and Treatment of Gas Gangrene. The preparation is used for prevention and treatment of gas gangrene. As a preventive measure the serum is administered intramuscularly, whereas therapeutic administration is performed by means of intravenous infusion.
Concentrated antigangrene serum is composed of purified polyvalent proteins fraction of the equine serum containing specific immunoglobulins. This serum is obtained from equines been hyper-immunized with anatoxins (toxins) mix of three main agents, responsible for the symptoms of septic anaerobic infection (A-type Cl. perfringens, Cl. novyi (oedematiens) and Cl. septicum). The serum contains purified peptides with Cresol < 0.25% v/v as a preservative. The serum is supplied as a liquid polyvalent formulation. One vial in the pack contains mixture of anti-toxins against 3 causative agents, which are common for clinical cases of gas gangrene.
Therapeutical effect of polyvalent antigangrene serum is provided by the specific antibodies contained in the preparation. The antibodies selectively neutralize the toxins derived by propagating anaerobic microbes (A-type Cl. perfringens, Cl. novae (oedematiens) and Cl. septicum).
Antigangrene serum may be used both to treat or prevent development of the "gas gangrene" and some syndromes resulted from septic infections such as anaerobic sepsis, pulmonary gangrene etc. Prior the vaccinating, the probe for individual sensitivity must be taken with intracutaneous injection of equines serum (0.1 ml, 1100), administered to the inner elbow area. Then, the reaction is recognized as a negative, if in 30 min the spot area of injection appears like having less than 1 cm in diameter. Serum has to be administered to the patient in the possibly shortest time after getting injuries. Prophylactic dose (25000 I.U.) may be administered with intramuscular injection. If the reaction of individual sensitivity shown as positive (> 1 cm in diameter) then the serum must be administered gradually with several dilutions of 0.1 ml of serum in 9.9 ml of PSS. The doses to test allergic response are 0.5 ml, 2 ml and 5ml. If these doses are well tolerated then the final test is performed with intramuscular injection of 0.1 ml of antigangrene serum followed by complete therapeutic dose. Clinical treatment of gangrene with the serum is featured as a slow intravenous infusion of the serum (150000 I.U.), diluted with equal volume of preheated to 36.5 C PSS. The speed of perfusion is 5 min for the first 1 ml of serum, then infusion is continued with 1 ml/min.
There are no known contraindications to use the preparation of antigangrene serum.